Name: 脳卒中の機能評価のコンピューター適応型テスト システム (動画) | JoVE Journal
Uploaded: 2019-01-07T14:00:00.000+00:00
Duration: 5 min 21 s
Description: 学ぶCAT-FASによる脳卒中患者の上肢・下肢運動機能、姿勢制御、日常生活動作の評価法。301例の臨床データに基づき、信頼性と効率性を向上させるコンピューター適応型テストシステムの構築と検証を解説する。

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This study was supported by research grants from the Ministry of Science and Technology (105-2314-B-002 -015 -MY3).

This study protocol was approved by a local institutional review board, and all patients gave informed consent.
1. Development of the CAT-FAS
<ol>
	<li>Retrieve the secondary and encrypted data from the FAS study14 to conduct simulations (Supplementary File 1: Appendix 2). 
	NOTE: In the study, a total of 301 patients were recruited froma rehabilitation ward of a medical center and assessed at 14 d after stroke onset. Among the 301 patients, 262 patients were repeatedly assessed at 30 d after stroke onset. The study recruited patients who had (1) a diagnosis of stroke, (2) first onset of stroke, (3) onset of stroke within 14 d before hospitalization, (4) the ability to follow commands, and (5) the ability to give informed consent personally or by proxy. Patients who had other major diseases were excluded. In each assessment session, patients were assessed with the FM, PASS, and BI by a well-trained occupational therapist (Supplementary File 1: Appendices 3-5).
	<ol>
		<li>Establish the item bank of the CAT-FAS by adopting the item bank of the FAS (Supplementary File 1: Appendix 2A). 
		NOTE: The item bank has sufficient items fit the Rasch partial credit model15,16 and covers a wide range of item difficulties. The item bank contains 58 items (Supplementary File 1: Appendix 3) selected from the FM-UE (26 items), FM-LE (11 items), PASS (12 items), and BI (nine items).</li>
		<li>Retrieve the item difficulties of all items in the item bank from the FAS study (Supplementary File 1: Appendix 2A - Item difficulty). 
		NOTE: Each item in the item bank has a set of parameters to depict the difficulty of the item (i.e., item difficulties), which are estimated by the Rasch partial credit model. The CAT-FAS uses the item difficulties to (1) select items with difficulties tailored to the examinee&#39;s level of function (step 1.3.3) and (2) estimate the examinee&#39;s level of function (step 1.3.5).</li>
		<li>Retrieve each patient&#39;s responses (e.g., 0, 1, or 2 points) to the items of the item bank of the FAS (Supplementary File 1: Appendix 2B). 
		NOTE: In previous studies14, all items of the item bank of the FAS were administered to the patients. In this simulation study, these responses of the patients were retrieved and used as the simulated responses (patients were not administered by the CAT-FAS) to the items of the CAT-FAS (step 1.3.4).</li>
		<li>Retrieve the ability distribution (i.e., the standard deviation [SD] of the scores) of the patients in the four functions (BADL, postural control, and UE/LE motor functions; Supplementary File 1: Appendix 2C). 
		NOTE: The abilities of the patients in the four functions are the final scores of the assessment of the item bank (Supplementary File 1: Appendix 2C). The scores (and SD of the scores) of the four functions are estimated in a previous study14 by the Rasch partial credit model, based on the patients&#39; responses to each item (step 1.1.3). In this study, the SD of the scores is retrieved and used as prior information to calculate the reliability of the CAT-FAS (step 1.3.6).</li>
	</ol>
	</li>
	<li>Determine the operational algorithms of the CAT-FAS (Supplementary File 1: Appendix 7).
	<ol>
		<li>Adopt the maximum a posteriori (MAP) method for estimating each patient&#39;s scores of the four functions with Newton-Raphson iteration17.</li>
		<li>Use the criterion of D-optimality for the item selection18. An item with the maximum determinant of the Fisher information matrix is selected from the item bank for administration.</li>
		<li>Adopt 10 candidate sets of stopping rules for exploring the properties of the CAT-FAS via simulation (Supplementary File 1: Appendix 8). 
		NOTE: The first five candidate sets are &#34;reaching limited reliability increase (LRI) criterion&#34; (i.e., an LRI &#60; 0.001, &#60; 0.005, &#60; 0.010, &#60; 0.015, or &#60; 0.020). The other five candidate sets are &#34;reaching either LRI criterion or threshold of reliability&#34; (i.e., a Rasch reliability &#8805; 0.90, paired with the aforementioned five LRI criteria). The LRI and threshold of reliability are frequently adopted stopping rules in CATs13,17.</li>
	</ol>
	</li>
	<li>Explore the measurement reliability and efficiency (number of items needed for administration) of the CAT-FAS via steps 1.3.1 to 1.3.11 of simulation (Figure 1). 
	NOTE: Supplementary File 1: Appendix 9 shows the screenshot of the software.
	<ol>
		<li>Use a specified set of stopping rules (i.e., from the first to the last candidate sets of stopping rules which are in step 1.2.3, successively) to explore the properties of the CAT-FAS (Figure 1A).</li>
		<li>Set the initial CAT-FAS scores of the four functions (BADL, postural control, UE motor function, and LE motor function) to 0 for specified patients (i.e., from the first to the last patient in the data, successively; Figure 1B,C).</li>
		<li>Adaptively select an item with the maximum determinant of the Fisher information matrix (i.e., the criterion of D-optimality) from the item bank for administration (Figure 1D). 
		NOTE: The information matrix of each item is calculated based on a patient&#39;s scores of the four functions and the item&#39;s difficulty (from step 1.1.2). To ensure that the CAT-FAS administers at least one item in each function/domain, the first four items of the CAT-FAS are selected from the four functions.</li>
		<li>Obtain the patient&#39;s response to the selected item from step 1.1.3 (Figure 1E).</li>
		<li>Simultaneously estimate the CAT-FAS scores (and standard errors [SEs] of the scores) of the four functions using the MAP method with an iterative Newton-Raphson process (Figure 1F).19 During the iterative Newton-Raphson process, renew the scores and SEs of the four functions in each iteration until the criterion of convergence is met. Convergence occurs when the differences in scores between two consecutive iterations are &#60;0.001.</li>
		<li>Count the number of items which are administered, save the latest renewed CAT-FAS scores (and SEs), and calculate the individual-level Rasch reliability of each function using the following formula: 
		1 - ([SE2 of step 1.3.5] / [SD2 of the scores of step 1.1.4]).</li>
		<li>Calculate the LRI using the last renewed individual-level Rasch reliability (step 1.3.6) minus that of the previous estimation (Figure 1G).</li>
		<li>Check whether the specified set (e.g., the first candidate set) of stopping rules is met (Figure 1H). If not, repeat steps 1.3.3 - 1.3.8 until the specified set of stopping rules is met. If so, save the latest renewed CAT-FAS scores (and SEs) as the final CAT-FAS scores (and SEs).</li>
		<li>Repeat steps 1.3.2 to 1.3.8 until all patients&#39; administrations are completed (Figure 1I).</li>
		<li>Finish the simulation of the CAT-FAS with the specific set of stopping rules and save the results of the simulation (Figure 1J). 
		NOTE: The results should include (1) the final CAT-FAS scores (and SEs) of the four functions, (2) the number of items needed to complete the CAT-FAS, (3) the Rasch reliability of each patient (i.e., individual-level Rasch reliability), and (4) the average Rasch reliability of all patients.</li>
		<li>Repeat steps 1.3.1 to 1.3.11 to explore the properties of the CAT-FAS with other candidate sets of stopping rules until all candidate sets of stopping rules are explored (Figure 1K).</li>
	</ol>
	</li>
	<li>Select the final set of stopping rules for the CAT-FAS according to the average Rasch reliability of &#8805;0.90 in at least three functions and the average items of administration of &#8804;10.0.</li>
	<li>Develop an online administration platform for the CAT-FAS by writing a computer program to establish a website (Supplementary File 1: Appendix 10).</li>
</ol>
2. Administration of the CAT-FAS
<ol>
	<li>Connect the examiner&#39;s electronic device (e.g., personal computer, tablet, or smartphone) to the online administration platform of the CAT-FAS using an internet browser.</li>
	<li>Log in to the administration system (Supplementary File 1: Appendix 11).</li>
	<li>Click Data management to access data from previous examinees (Supplementary File 1: Appendix 12).</li>
	<li>Click New examinee to create an account for a new examinee by entering the examinee&#39;s name and ID number.</li>
	<li>Select an examinee and click Start (Supplementary File 1: Appendix 13).</li>
	<li>Click New assessment to create a new assessment or click Results to review the results of the examinee&#39;s previous assessments.</li>
	<li>Administer the items shown on the screen to the examinee (Supplementary File 1: Appendix 14).</li>
	<li>Rate the examinee&#39;s performance or responses by clicking the rating scale shown at the bottom of the screen(Supplementary File 1: Appendix 14).</li>
	<li>Explain the results of the CAT-FAS to the examinee, including the T-scores with a 95% interval, the percentile ranks of the T-scores, and the reliabilities of the four functions of the CAT-FAS. These results are calculated and shown automatically by the CAT-FAS (Supplementary File 1: Appendix 15).</li>
	<li>Click OK and return to the Data management page.</li>
</ol>

<ol><li>Kim, S. S., Lee, H. J., You, Y. Y. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Effects+of+ankle+strengthening+exercises+combined+with+motor+imagery+training+on+the+timed+up+and+go+test+score+and+weight+bearing+ratio+in+stroke+patients%5BTitle%5D)+AND+%22Journal+of+Physical+Therapy+Science%22%5BJournal%5D)">Effects of ankle strengthening exercises combined with motor imagery training on the timed up and go test score and weight bearing ratio in stroke patients.</a> Journal of Physical Therapy Science. 27 (7), 2303-2305 (2015).</li>
<li>Langhorne, P., Coupar, F., Pollock, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Motor+recovery+after+stroke%3A+A+systematic+review%5BTitle%5D)+AND+%22Lancet+Neurology%22%5BJournal%5D)">Motor recovery after stroke: A systematic review.</a> Lancet Neurology. 8 (8), 741-754 (2009).</li>
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<li>Fugl-Meyer, A. R., Jaasko, L., Leyman, I., Olsson, S., Steglind, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((The+post-stroke+hemiplegic+patient+1%3A+A+method+for+evaluation+of+physical+performance%5BTitle%5D)+AND+%22Scandinavian+Journal+of+Rehabilitation+Medicine%22%5BJournal%5D)">The post-stroke hemiplegic patient 1: A method for evaluation of physical performance.</a> Scandinavian Journal of Rehabilitation Medicine. 7 (1), 13-31 (1975).</li>
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<li>Mahoney, F. I., Barthel, D. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Functional+Evaluation%3A+The+Barthel+Index%5BTitle%5D)+AND+%22Maryland+State+Medical+Journal%22%5BJournal%5D)">Functional Evaluation: The Barthel Index.</a> Maryland State Medical Journal. 14, 61-65 (1965).</li>
<li>Duffy, L., Gajree, S., Langhorne, P., Stott, D. J., Quinn, T. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Reliability+%28inter-rater+agreement%29+of+the+Barthel+Index+for+assessment+of+stroke+survivors%3A+Systematic+review+and+meta-analysis%5BTitle%5D)+AND+%22Stroke%22%5BJournal%5D)">Reliability (inter-rater agreement) of the Barthel Index for assessment of stroke survivors: Systematic review and meta-analysis.</a> Stroke. 44 (2), 462-468 (2013).</li>
<li>Lin, J. H., Hsueh, I. P., Sheu, C. F., Hsieh, C. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Psychometric+properties+of+the+sensory+scale+of+the+Fugl-Meyer+Assessment+in+stroke+patients%5BTitle%5D)+AND+%22Clinical+Rehabilitation%22%5BJournal%5D)">Psychometric properties of the sensory scale of the Fugl-Meyer Assessment in stroke patients.</a> Clinical Rehabilitation. 18 (4), 391-397 (2004).</li>
<li>Mao, H. F., Hsueh, I. P., Tang, P. F., Sheu, C. F., Hsieh, C. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Analysis+and+comparison+of+the+psychometric+properties+of+three+balance+measures+for+stroke+patients%5BTitle%5D)+AND+%22Stroke%22%5BJournal%5D)">Analysis and comparison of the psychometric properties of three balance measures for stroke patients.</a> Stroke. 33 (4), 1022-1027 (2002).</li>
<li>Hsueh, I. P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Development+of+a+computerized+adaptive+test+for+assessing+balance+function+in+patients+with+stroke%5BTitle%5D)+AND+%22Physical+Therapy%22%5BJournal%5D)">Development of a computerized adaptive test for assessing balance function in patients with stroke.</a> Physical Therapy. 90 (9), 1336-1344 (2010).</li>
<li>Hsueh, I. P., Chen, J. H., Wang, C. H., Hou, W. H., Hsieh, C. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Development+of+a+computerized+adaptive+test+for+assessing+activities+of+daily+living+in+outpatients+with+stroke%5BTitle%5D)+AND+%22Physical+Therapy%22%5BJournal%5D)">Development of a computerized adaptive test for assessing activities of daily living in outpatients with stroke.</a> Physical Therapy. 93 (5), 681-693 (2013).</li>
<li>Wong, A. W., Heinemann, A. W., Miskovic, A., Semik, P., Snyder, T. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Feasibility+of+computerized+adaptive+testing+for+collection+of+patient-reported+outcomes+after+inpatient+rehabilitation%5BTitle%5D)+AND+%22Archives+of+Physical+Medicine+and+Rehabilitation%22%5BJournal%5D)">Feasibility of computerized adaptive testing for collection of patient-reported outcomes after inpatient rehabilitation.</a> Archives of Physical Medicine and Rehabilitation. 95 (5), 882-891 (2014).</li>
<li>Lin, G. H., Huang, Y. J., Lee, S. C., Huang, S. L., Hsieh, C. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Development+of+a+computerized+adaptive+testing+system+of+the+Functional+Assessment+of+Stroke%5BTitle%5D)+AND+%22Archives+of+Physical+Medicine+and+Rehabilitation%22%5BJournal%5D)">Development of a computerized adaptive testing system of the Functional Assessment of Stroke.</a> Archives of Physical Medicine and Rehabilitation. 99 (4), 676-683 (2017).</li>
<li>Wang, Y. L., Lin, G. H., Yi-Jing, H., Chen, M. H., Hsieh, C. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Refining+three+measures+to+construct+an+efficient+Functional+Assessment+of+Stroke%5BTitle%5D)+AND+%22Stroke%22%5BJournal%5D)">Refining three measures to construct an efficient Functional Assessment of Stroke.</a> Stroke. 48 (6), 1630-1635 (2017).</li>
<li>Adams, R. J., Wilson, M., Wang, W. C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((The+multidimensional+random+coefficients+multinomial+logit+model%5BTitle%5D)+AND+%22Applied+Psychological+Measurement%22%5BJournal%5D)">The multidimensional random coefficients multinomial logit model.</a> Applied Psychological Measurement. 21 (1), 1-23 (1997).</li>
<li>Masters, G. N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((A+Rasch+model+for+partial+credit+scoring%5BTitle%5D)+AND+%22Psychometrika%22%5BJournal%5D)">A Rasch model for partial credit scoring.</a> Psychometrika. 47 (2), 149-174 (1982).</li>
<li>Wang, W. C., Chen, P. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Implementation+and+measurement+efficiency+of+multidimensional+computerized+adaptive+testing%5BTitle%5D)+AND+%22Applied+Psychological+Measurement%22%5BJournal%5D)">Implementation and measurement efficiency of multidimensional computerized adaptive testing.</a> Applied Psychological Measurement. 28 (5), 295-316 (2004).</li>
<li>Mulder, J., Van der Linden, W. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Multidimensional+adaptive+testing+with+optimal+design+criteria+for+item+selection%5BTitle%5D)+AND+%22Psychometrika%22%5BJournal%5D)">Multidimensional adaptive testing with optimal design criteria for item selection.</a> Psychometrika. 74 (2), 273-296 (2009).</li>
<li>Segall, D. O. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((General+ability+measurement%3A+An+application+of+multidimensional+item+response+theory%5BTitle%5D)+AND+%22Psychometrika%22%5BJournal%5D)">General ability measurement: An application of multidimensional item response theory.</a> Psychometrika. 66 (1), 79-97 (2001).</li>
<li>Lee, S. C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Development+of+a+social+functioning+assessment+using+computerized+adaptive+testing+for+patients+with+stroke%5BTitle%5D)+AND+%22Archives+of+Physical+Medicine+and+Rehabilitation%22%5BJournal%5D)">Development of a social functioning assessment using computerized adaptive testing for patients with stroke.</a> Archives of Physical Medicine and Rehabilitation. 99 (2), 306-313 (2018).</li>
<li>Paap, M. C. S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Measuring+patient-reported+outcomes+adaptively%3A+Multidimensionality+matters%21%5BTitle%5D)+AND+%22Applied+Psychological+Measurement%22%5BJournal%5D)">Measuring patient-reported outcomes adaptively: Multidimensionality matters!</a> Applied Psychological Measurement. 42 (5), 327-342 (2018).</li>
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</ol>

The authors have nothing to disclose.

The results presented here showed that the CAT-FAS administered about 10% of the items in the original tests (the average number of items used in the CAT-FAS: 8.5 items vs. the original tests: 72 items). These findings indicate that the CAT-FAS has good administrative efficiency. The results were in line with previous studies, which reported that a CAT administered only about 10 items or less to assess social function, balance, or activities of daily living in patients with stroke10,...

Dysfunctions of the upper and lower extremities (UE and LE), postural control, and basic activities of daily living (BADL) are major sequelae of stroke1,2,3. The assessment of these four functions in patients with stroke is fundamental for clinicians to evaluate patients' levels of dysfunctions, set treatment goals and plans, and monitor the longitudinal trajectories of these functions.
The Fugl-Meyer Assessment (FM),4 the Postural Assessment Scale for Stroke patients (PASS),5 and the Barthel Index (BI)6 have good psychometric properties to assess the UE/LE motor functions, postural control, and BADL, respectively, in patients with stroke7,8,9. However, the total of 72 items from these three measures impedes the feasibility of assessing all three measures within a time-limited therapeutic session. A more efficient testing method is warranted. Computerized adaptive testing (CAT) is a modern measurement method. Compared with conventional measurement methods, CAT provides a more reliable estimate of the examinee's level of function in much less time10,11,12. In conventional measurement methods, each examinee receives the same test form (or item sets), in which many items are too difficult or too easy for the examinee. These items provide limited information for estimating the examinee's level of function and are time-intensive for examinees. In contrast, in CAT, each examinee gets a tailored item set, in which the difficulty level of the selected items meets the function level of the examinee. Because these items are tailored for that particular examinee, CAT can provide a more reliable estimate of the examinee's level of function with fewer items and, thus, in much less time. The steps of CAT development are shown in Supplementary File 1: Appendix 1.
Because CAT promises reliable and efficient assessments, the CAT-FAS was developed to improve the administrative efficiency of the three measures previously used (FM, PASS, and BI)13. This paper describes the development and administration of the CAT-FAS. This protocol provides information for researchers to develop their CATs and for prospective users of the CAT-FAS to administer it. We also address the strengths and weaknesses of the CAT-FAS.

<table><tbody><tr><td>Computer</td><td>Any</td><td></td><td>Compatible with software listed below</td></tr><tr><td>MATLAB software</td><td>The MathWorks Inc.</td><td>http://www.mathworks.com/products/matlab/</td><td>Numerical computing software, which is used in the Protocol Section 1 (Step 1.3)</td></tr><tr><td>Java Development Kit</td><td>Oracle</td><td>https://www.oracle.com/java/</td><td>Programming language, which is used in the Protocol Section 1 (Step 1.5)</td></tr></tbody></table>

computerized adaptive testing system of functional assessment of stroke

Computerized Adaptive Testing System of Functional Assessment of Stroke

The computerized adaptive testing system of the functional assessment of stroke (CAT-FAS) can simultaneously assess four functions (motor functions of the upper and lower extremities, postural control, and basic activities of daily living) with sufficient reliability and administrative efficiency. CAT, a modern measurement method, aims to provide a reliable estimate of the examinee's level of function rapidly. CAT administers only a few items whose item difficulties match an examinee's level of function and, thus, the administered items of CAT can provide sufficient information to reliably estimate the examinee's level of function in a short time. The CAT-FAS was developed through four steps: (1) determining the item bank, (2) determining the stopping rules, (3) validating the CAT-FAS, and (4) establishing a platform of online administration. The results of this study indicate that the CAT-FAS has sufficient administrative efficiency (average number of items = 8.5) and reliability (group-level Rasch reliability: 0.88 - 0.93; individual-level Rasch reliability: &#8805;70% of patients had Rasch reliability score &#8805;0.90) to simultaneously assess four functions in patients with stroke. In addition, because the CAT-FAS is a computer-based test, the CAT-FAS has three additional advantages: the automatic calculation of scores, the immediate storage of data, and the easy exporting of data. These advantages of the CAT-FAS will be beneficial to data management for clinicians and researchers.

The results of the simulation showed that the 10 candidate sets of stopping rules had sufficient average Rasch reliability (0.86 - 0.95) and varied administrative efficiency (the average number of items = 6.4 - 17.5). Considering the trade-off between reliability and administrative efficiency, the set of LRI &lt; 0.010 was selected as the optimal set of stopping rules for the CAT-FAS because of its sufficient average Rasch reliability (0.88 - 0.93, see Table 1</st...

Here, we present a protocol to develop the computerized adaptive testing system of the functional assessment of stroke (CAT-FAS). The CAT-FAS can simultaneously assess four functions (two motor functions [upper and lower extremities], postural control, and basic activities of daily living) with sufficient reliability and administrative efficiency.

The computerized adaptive testing system of the functional assessment of stroke (CAT-FAS) can simultaneously assess four functions (motor functions of the ...

The overall goal of this test development study is to develop a computerized adaptive testing system to assess the functions of the upper extremity, lower extremity, balance, and activities of daily living in stroke patients. No other tractive efficiency is found in assessing the functions of upper extremity, lower extremity, balance, and activities of daily living with patients of stroke. The computerized adaptive testing of the functional assessment of stroke was developed to improve the tractive efficiency of the full functions in patients with stroke.Begin by retrieving the secondary and encrypted data from the functional assessment of stroke study to conduct a simulation. In this study, 301 patients were recruited from a medical center rehabilitation ward, and assessed at 14 days post-stroke onset. In each assessment session, patients were assessed by a well-trained occupational therapist using the Fugl Meyer Assessment, the Postural Assessment Scale for Stroke Patients, and the Barthel Index.Establish an item bank for the testing system by adopting the bank from the study. Retrieve the item difficulties of all items in the bank, as well as each patient's responses. Also retri

computerized-adaptive-testing-system-functional-assessment

Research

JoVE Journal

Behavior

This training protocol uses computerized training to teach technology-related everyday functional skills. These skills include financial skills, travel and transit, as well as medication management.

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills

Clinical assessment scales are notsensitive enough to cognitive dysfunction in high-functioning stroke patients. The dual-task paradigm presents advantages and potential in the assessment and cognitive training of cognitive dysfunction. The study here proposes a dual-task Stroop paradigm to identify cognitive dysfunction in high-functioning stroke patients.

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

The purpose of this study is to provide an important reference for the standard clinical operation of motor imagery brain-computer interface (MI-BCI) for upper limb motor dysfunction after stroke.

Motor Imagery Brain-Computer Interface in Rehabilitation of Upper Limb Motor Dysfunction After Stroke

The current protocol outlines how the VR-based digital occupational training system enhances the rehabilitation of patients with cognitive impairment and upper limb dysfunction following a stroke.

Cognitive Function and Upper Limb Rehabilitation Training Post-Stroke Using a Digital Occupational Training System

The Multimedia Battery for Assessment of General-Domain and Specific-Domain Skills in Reading is a reliable and valid multimedia battery designed to assess cognitive and basic reading skills. It enables the generation of a comprehensive cognitive and reading performance profile, which is particularly beneficial for children with dyslexia.

Advancing Dyslexia Assessment in Children Through Computerized Testing

This article describes the procedure of transcranial pulse stimulation in patients with Alzheimer's disease. It discusses the indications, methodology, and future prospects in detail.

Transcranial Pulse Stimulation for Alzheimer's Patients

This study presents a novel transcranial direct current stimulation (tDCS) protocol combined with cognitive stimulation to address post-stroke hemispatial neglect. Initial data from a pilot patient ensure the procedure's feasibility and suggest potential efficacy, providing a foundation for a future parallel, triple-blind, controlled clinical trial.

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Mouse models have become increasingly popular in studies of behavioral neuroscience.  As models advance, it is important to develop sensitive behavioral measures specific to the mouse.  This protocol describes the Pasta Matrix Reaching Task, which is a skilled motor task for use in mouse models of stroke.

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Motor control and balance performance are known to deteriorate with age. This paper presents a number of standard noninvasive behavioral tests with the addition of a simple rotary stimulus to challenge the vestibular system and show changes in balance performance in a murine model of aging.

Behavioral Assessment of the Aging Mouse Vestibular System

Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique. It has successfully been used in basic research and clinical settings to modulate brain function in humans. This article describes the implementation of tDCS and simultaneous functional magnetic resonance imaging (fMRI), to investigate the neural basis of tDCS effects.

Transcranial Direct Current Stimulation and Simultaneous  Functional Magnetic Resonance Imaging

学ぶCAT-FASによる脳卒中患者の上肢・下肢運動機能、姿勢制御、日常生活動作の評価法。301例の臨床データに基づき、信頼性と効率性を向上させるコンピューター適応型テストシステムの構築と検証を解説する。

Computerized Adaptive Testing System of Functional Assessment of Stroke

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