Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

267 مشاهدة

استشهد بها 8

11:04 دقيقة

سبتمبر 1, 2014

10.3791/51471-v

سبتمبر 1, 2014

267 مشاهدة

Sina Mossahebi²^,⁵ , Simeng Zhu²^,⁵ , Howard Chen¹^,⁵ , Leonid Shmuylovich³^,⁵ , Erina Ghosh¹^,⁵ , Sándor J. Kovács⁴^,⁵

¹Department of Biomedical Engineering, Washington University in St. Louis, ²Department of Physics, Washington University in St. Louis, ³Division of Biology and Biomedical Sciences, Washington University in St. Louis, ⁴Department of Medicine, Cardiovascular Division, Washington University in St. Louis, ⁵Cardiovascular Biophysics Lab, Washington University in St. Louis

Accurate, causality-based quantification of global diastolic function has been achieved by kinematic modeling-based analysis of transmitral flow via the Parametrized Diastolic Filling (PDF) formalism. PDF generates unique stiffness, relaxation, and load parameters and elucidates 'new' physiology while providing sensitive and specific indexes of dysfunction.